Every Cure

Every Cure is a nonprofit on a mission to save and improve lives by repurposing existing medicines. We work across all drugs and all diseases to systematically identify the highest potential repurposing opportunities.

Datasets on HuggingFace

Our current datasets include:

Drug list: the drugs we consider for repurposing opportunities
Disease list: the diseases we consider for repurposing opportunities
KG Nodes & Edges: One of the methods we use to predict repurposing opportunities is based on knowledge graphs. We combine multiple upstream KGs and data sources to build an integrated KG. For a high level overview of the data, check our data dashboard. The nodes and edges of our integarted graph are available for download below.
matrix-scores: the latest predictions for all drug-disease pairs from our KG-based method. These are updated approximately quarterly. A heatmap application allows exploration of these scores. Please note these scores indicate biological plausibility, not repurposing potential.

Code & Documentation

Resource	Link
Main platform repo	github.com/everycure-org/matrix
Tech docs	docs.dev.everycure.org
All repos	github.com/everycure-org

Publications

Lancet Haematology (2025) — Pioneering a new field of computational pharmacophenomics to unlock the life-saving potential of existing medicines. Fajgenbaum DC et al. everycure.org/lancet
Platform paper (preprint, 2025) — Every Cure's End-to-End AI-Enabled Drug Repurposing Platform: Integrating Human-in-the-Loop Expertise to Accelerate Impact. DOI: 10.58647/REXPO.25000098.v1
MeDI (under submission) — MeDI: A Foundational Database to Support Drug Repurposing — covers the MATRIX drug and disease list creation process.
Unmet Medical Need Index (PLOS Medicine, in review) — Unmet Medical Need Index: A Large Language Model-based methodology to Quantify Unmet Medical Need across the Disease Landscape — covers the methodology behind our Unmet Medical Need assessments.

Programs

Active repurposing programs portfolio

Disclaimer

The scores and predictions shared by Every Cure are the output of a computational research pipeline and are intended for research purposes only. They do not constitute medical advice, clinical recommendations, or endorsement of any drug for any use. Every Cure makes no warranties, express or implied, regarding the accuracy, completeness, or fitness for any particular purpose of the information presented. Drug repurposing opportunities identified here require rigorous independent scientific and clinical validation before any clinical application.